Modeled structure of trypanothione reductase of Leishmania infantum |
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Authors: | Singh Bishal K Sarkar Nandini Jagannadham M V Dubey Vikash K |
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Institution: | Department of Biotechnology, Indian Institute of Technology Guwahati, Assam-781039, India. |
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Abstract: | Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity. |
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