A predictive model for the spontaneous synchronization of Saccharomyces cerevisiae grown in continuous culture. I. Concept |
| |
| Affiliation: | 1. Laboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China;2. Supervision, Inspection, and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing 100083, China;1. Cell and Molecular Therapies (CMT) and Institute of Haematology, Royal Prince Alfred Hospital (RPAH), Australia;2. Gene and Stem Cell Therapy Program, Centenary Institute, Australia;3. Sydney Medical School, University of Sydney, Camperdown, NSW, Australia;1. Politecnico di Milano, Dipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Piazza Leonardo da Vinci 32, 20133 Milano, Italy;2. Purdue University, School of Chemical Engineering, Forney Hall of Chemical Engineering, 480 Stadium Mall Drive, West Lafayette, IN 47907-2100, United States;3. Università degli Studi dell׳Insubria, Dip. di Scienza e Alta Tecnologia, Via G. B. Vico 46, 21100 Varese, Italy;4. Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, 20133 Milano, Italy |
| |
| Abstract: | A structured segregated model was developed for studying spontaneous oscillations of S. cerevisiae in continuous culture. The model is based on cells of a simple metabolic structure and assumptions about the modification of this structure during the cell cycle. The most important features of the model cells are the ability to grow on ethanol and glucose simultaneously in continuous culture, the accumulation of intracellular storage carbohydrates during the single cell phase and their mobilization during the budding phase. The model predicts oscillations of considerable similarity to those observed in experiments. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
