Plasminogen endowed with magnetic property |
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Affiliation: | 1. Agriculture Microbiology Department, National Research Centre, Dokki, Cairo, Egypt;2. Botany Department, Faculty of Science, Tanta University, Tanta, Egypt;3. Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, China |
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Abstract: | Plasminogen was modified with an activated magnetic modifier, which consists of magnetite (Fe3O4) and a polyethylene glycol derivative. The magnetic plasminogen was activated with urokinase and became a magnetic derivative of plasmin. The magnetic plasmin exhibited specific activity which is 32% of the native plasmin; 7.0 versus 22 casein units mg−1 protein. It was readily attracted by a magnet (250 Oe). It is particularly worth mentioning that the magnetic plasmin was more resistant to plasmin inhibitor(s) in plasma than plasmin. By applying magnetic force, the magnetic plasmin was attracted at the site of fibrin clot and local fibrinolysis was achieved in saline-circulating system. |
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