Regulation of intracellular pH in rat uterine smooth muscle,studied by 31P NMR spectroscopy |
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| Affiliation: | The MRC Biomedical NMR Centre, London U.K. |
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| Abstract: | Intracellular pH (pHi) affects smooth muscle function, yet little is known concerning its regulation. I have therefore investigated pH regulation in rat uterus, using 31P-NMR spectroscopy. A change in extracellular pH(pHe) of 1 pH unit (7.4 to 6.4) elicited a 0.29 change in pHi; smaller changes in pHo were accompanied by proportionately smaller changes in pHi. The pH changes were reversible. There was no fall of uterine ATP or phosphocreatine during the pH changes. |
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