A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles |
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| Authors: | Gudrun Schappacher-Tilp Timothy Leonard Gertrud Desch Walter Herzog |
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| Affiliation: | 1. Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.; 2. Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada.; Semmelweis University, HUNGARY, |
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| Abstract: | We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap. |
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