Synthesis of condensed quinolines and quinazolines as DNA ligands |
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| Authors: | Malecki Natacha Carato Pascal Rigo Benoît Goossens Jean-François Houssin Raymond Bailly Christian Hénichart Jean-Pierre |
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| Affiliation: | Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France. |
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| Abstract: | Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition. |
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