The X protein of borna disease virus serves essential functions in the viral multiplication cycle |
| |
Authors: | Poenisch Marion Wille Sandra Ackermann Andreas Staeheli Peter Schneider Urs |
| |
Institution: | Department of Virology, University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany. |
| |
Abstract: | The X gene of Borna disease virus (BDV) encodes a nonstructural 10-kDa protein that can interact with viral polymerase cofactor P, thus regulating polymerase activity. It remained unknown whether X is essential for virus multiplication. All our attempts to generate mutant BDV with a nonfunctional X gene proved unsuccessful. However, a mutant virus with an inactive X gene was able to replicate in Vero cells if an artificial gene cassette encoding X was inserted at a site near the 5' end of the viral genome. These results indicate that X performs essential viral functions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|