Modulation of rabbit mitochondrial nuclease activity by S-adenosyl-L-methionine |
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| Authors: | D. E. Sobolev B. F. Vanyushin |
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| Affiliation: | 14168. Research Institute of Agricultural Biotechnology of the Russian Academy of Agricultural Sciences, ul. Timiryazevskaya 42, Moscow, 127550, Russia
24168. Belozersky Institute of Physicochemical Biology, Moscow State University, Moscow, 119991, Russia
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| Abstract: | Endonuclease activity with properties similar to those of the animal endonuclease G has been detected in extracts of rabbit liver mitochondria. This activity was detected in the fraction of proteins with molecular mass close to 30 kDa; it was stimulated by Mg2+ ions and inhibited by Zn2+ ions. In contrast to plant endonucleases WEN1 and WEN2, the rabbit endonuclease was not affected by methylation status of the substrate DNA, and S-adenosine-L-methionine inhibited it. |
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