Modulation of rabbit mitochondrial nuclease activity by S-adenosyl-L-methionine |
| |
| Authors: | D E Sobolev B F Vanyushin |
| |
| Institution: | 14168. Research Institute of Agricultural Biotechnology of the Russian Academy of Agricultural Sciences, ul. Timiryazevskaya 42, Moscow, 127550, Russia
24168. Belozersky Institute of Physicochemical Biology, Moscow State University, Moscow, 119991, Russia
|
| |
| Abstract: | Endonuclease activity with properties similar to those of the animal endonuclease G has been detected in extracts of rabbit liver mitochondria. This activity was detected in the fraction of proteins with molecular mass close to 30 kDa; it was stimulated by Mg2+ ions and inhibited by Zn2+ ions. In contrast to plant endonucleases WEN1 and WEN2, the rabbit endonuclease was not affected by methylation status of the substrate DNA, and S-adenosine-L-methionine inhibited it. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
