Toll样受体（TLR）介导的天然免疫间的相互调节

模式识别受体（PRR）在宿主细胞识别与抵御微生物病原体中起到了重要作用。Toll样受体（TLR）是研究比较清楚的一类PRR，可以识别多种病原体成份，启动天然免疫反应。此外，近来发现了几类其他模式识别受体，如C型凝集素受体（CLR），核苷酸寡聚结合域（NOD）样受体（NLR）和视黄酸诱导基因I（RIG—I）样受体（RLR），表明机体的天然免疫反应受到多种机制的精密调控。本文着重综述TLR与其他PRR在识别病原体和介导天然免疫信号通路间的相互关系。

The crosstalk of innate immune signaling mediated by different type of toll-like receptors(TLR)

Pattern recognition receptors （PRR） play a central role in host cell recognition and re- sponses to microbial pathogens. The best-characterized PRRs are Toll-like receptors （TLR）, which recog- nize numerous components of pathogens and initiate innate immune responses. The recent discovery of other types of PRR, such as C-type lectin receptors （CLR）, NOD-like receptors （NLR）, and RIG-I-like receptors （RLR）, suggests that the innate immune responses are tightly controlled by multiple mechanisms. In this review, we will focus on the crosstalk between TLR- and other PRR-initiated signaling pathways.