Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis |
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Authors: | Sasaki Motoko Ikeda Hiroko Ohira Shusaku Ishikawa Akira Nakanuma Yasuni |
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Institution: | Department of Human Pathology, Kanazawa University Graduate School of Medicine, 920-8640, Japan. m8sasaki@med.kanazawa-u.ac.jp |
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Abstract: | Trefoil factor family (TFF) 1, 2, and 3 is a mucin-associated protein involved in the maintenance of mucosal barrier and restitution of lining epithelial cells. In this study, the expression of TFF1, 2, and 3 and MUC mucins were examined immunohistochemically in hepatolithiasis and control livers. The expression of TFF1, 2, and 3 were augmented markedly in biliary mucosa in hepatolithiasis in coordinate with gel-forming mucin. TFF3 was detected in hepatic bile samples of hepatolithiasis. Augmented expression and secretion of TFF in biliary mucosa in hepatolithiasis may play a role in lithogenesis together with gel-forming mucin in addition to mucosal defense and repair. |
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