Cytotoxic polyketides from endophytic fungus Phoma bellidis harbored in Ttricyrtis maculate |
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| Institution: | 1. Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan;2. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan;3. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;4. Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;5. Research & Development Division, MicroBioPharm Japan Co Ltd., Aichi 452-0915, Japan;6. Present address: Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Okinawa 903-0213, Japan;1. Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an, 223003, China;2. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China;3. School of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China;4. Ocean College, Zhejiang University, Hangzhou, 310058, China;1. Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa;2. School of Pharmacy, University of Namibia, Private Bag 13301, Windhoek, Namibia;3. Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, 6140, South Africa;4. Department of Chemistry, The University of Western Ontario, London, Ontario, N6A 5B7 Canada;5. Department of Biological Sciences, University of Cape Town, Private Bag, Rondebosch, South Africa;6. Department of Chemistry, University of the Western Cape, Bellville, 7535, South Africa;7. School of Pharmacy, University of the Western Cape, Bellville, 7535, South Africa;1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China;2. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China;3. School of Life Sciences, University of Chinese Academy of Sciences, Yuquanlu 19A, Beijing, 100049, China |
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| Abstract: | Four new polyketides, namely bellidisins A-D (1-4), were isolated from rice fermentation extract of endophytic fungus Phoma bellidis, along with three known compounds pinolidoxin (5), 5,6-epoxypinolidoxin (6), and 2-epi-herbarumin II (7). Their structures and absolute configurations were determined by 1D and 2D NMR, HRESIMS and ECD calculation. Their cytotoxicity was evaluated against human cancer cell lines HL-60, A549, SMMC-7721, MCF-7, and SW480. Compound 4 showed significant cytotoxicity on these five cell lines with IC50 value ranged from 3.40 to 15.25 μM, which is stronger than cisplatin (4.86–27.70 μM). |
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| Keywords: | Endophytic fungus Decanolides Cytotoxicity |
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