Reproductive factors,obesity and risk of colorectal cancer in a cohort of Asian women |
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| Affiliation: | 1. Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #10-01, 117549, Singapore;2. National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore;3. National Registry of Diseases Office, Health Promotion Board, 3 Second Hospital Avenue, 168937, Singapore;4. Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore;1. Department of Ophthalmology, Central Hospital of Linyi, Yishui, Shandong, 276400, China;2. Department of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China;1. Department of Neurosurgery, Lariboisière Hospital, 75010 Paris, France;2. Victor Horsley Department of Neurosurgical, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK;3. INSERM U1153, Statistic and Epidemiologic Research Center Sorbonne Paris Cité (CRESS), ECSTRRA team, Université Diderot – Paris 7, USPC, Paris, France;4. Department of Medical Information, Sainte-Anne Hospital, 75014, Paris, France;5. Department of Medical Information, Georges Pompidou European Hospital, 75015, Paris, France;1. Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Av. Monforte de Lemos 3-5, 28029 Madrid, Spain;2. Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, C/ Universitat de Girona 10, 17003 Girona, Spain;3. Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Catalan Institute of Oncology, Carrer del Sol 15, 17004 Girona, Spain;4. Radiation Oncology Service, Josep Trueta University Hospital, Catalan Institute of Oncology, Avinguda de França, S/N, 17007 Girona, Spain;5. Hematological Laboratory Service, Germans Trias i Pujol University Hospital, Catalan Institute of Oncology, Josep Carreras Leukaemia Research Institute, Ctra. de Can Ruti Camí de les Escoles S/N, 8916 Badalona, Spain;6. Hematological Service, Josep Trueta University Hospital, Catalan Institute of Oncology, Avinguda de França, S/N, 17007 Girona, Spain;1. CONEVID, Unidad de Conocimiento y Evidencia, Universidad Peruana Cayetano Heredia, Lima, Peru;2. Faculty of Medicine, Universidad Nacional San Luis Gonzaga, Ica, Peru;3. Unidad de Investigación Básica y Traslacional, Oncosalud-AUNA, Lima, Peru;4. Facultad de Medicina "Alberto Hurtado", Universidad Peruana Cayetano Heredia, Lima, Peru;5. Cancer Center, The American British Cowdray Medical Center, Mexico City, Mexico;6. Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy;1. Department of Preventive Medicine and Public Health, School of Medicine, Avenida de la Investigación, 60, 18071, Granada, Spain;2. Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221, Belgrade, Serbia;3. Preventive Medicine Service, Hospital Universitario Virgen de las Nieves, Av. de las Fuerzas Armadas, 2, 18014 Granada, Spain;4. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029, Madrid, Spain;5. Instituto de Investigación Biosanitaria ibs.GRANADA, Complejo Hospitales Universitarios de Granada/Universidad de Granada, 18071, Granada, Spain |
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| Abstract: | BackgroundThis study evaluated reproductive factors and obesity in relation to colorectal cancer (CRC) in Asian women.MethodsThe study cohort comprised 28191 women who were recruited between 1994 and 1997. During 18 years of prospective follow-up, 404 and 212 women developed colon cancer (CC) and rectal cancer (RC) respectively. Cox proportional hazards regression was used.ResultsMenstrual factors were not related to the risk of CRC, CC and RC. Gravidity and parity were not associated with CRC or RC, but women who were ever pregnant had a HR of 1.87 (95%CI 1.12–3.14) compared to those never pregnant, and parous women had a HR of 1.79 (95% CI 1.10–2.92) compared to nulliparous women for CC. Use of oral contraceptives and hormone replacement therapy were not associated with CRC, CC or RC.Compared to women with normal BMI, women who were obese had HRs of 1.39 (95%CI 1.12–1.74) and 1.64 (95%CI 1.24–2.16) for CRC and CC respectively. No increased risk was seen for RC. Adjusted for BMI, for colonic cancer, women in the highest quartile for Waist Circumference had a HR of 2.14 (95%CI 1.42–3.25) compared to the lowest quartile, for Waist Hip Ratio, a HR of 1.74 (95%CI 1.30–2.34), and for Waist-Height ratio, a HR of 1.80 (1.26–2.57). None of these measures were significantly associated with RC.ConclusionsObesity is positively associated with CC but not RC, and abdominal obesity exerts an independent effect. Reproductive factors had at best a weak effect on CC and RC. |
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| Keywords: | Reproductive factors Obesity Colorectal cancer Cohort studies |
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