| 树突状细胞与肿瘤免疫 |
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| 引用本文： | 王冰,王红梅,徐方云,闵卫平.树突状细胞与肿瘤免疫[J].细胞生物学杂志,2013(11):1666-1671. |
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| 作者姓名： | 王冰 王红梅 徐方云 闵卫平 |
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| 作者单位： | [1]南昌大学医学院病理生理学教研室,南昌330006 [2]南昌大学医学院,南昌330006 [3]江西省医学科学研究院,南昌330006 |
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| 基金项目： | 国家自然科学基金（批准号：81160286、91229119）和江西省科技支撑计划资助的课题 |
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| 摘 要： | 树突状细胞（dendriticcells，Dcs）是目前已知的功能最强的抗原提呈细胞，具有调节免疫应答与诱导免疫耐受的能力。而树突状细胞所发挥的功能与其是否成熟有很大的关系，未成熟状态的树突状细胞具备致耐受性，而成熟状态的树突状细胞则对肿瘤免疫起着重要作用。该文将对DC的免疫学特性及Dc与肿瘤的关系予以综述。
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| 关 键 词： | 树突状细胞 异质性 肿瘤免疫 |
Relationship of Dendritic Cells and Tumor Immunity |
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| Wang Bing,#,Wang Hongmei,#,Xu Fangyun,Min Weiping.Relationship of Dendritic Cells and Tumor Immunity[J].Chinese Journal of Cell Biology,2013(11):1666-1671. |
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| Authors: | Wang Bing # Wang Hongmei # Xu Fangyun Min Weiping |
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| Institution: | 2＇3. ( Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China; 2Medical College of Nanchang University, Nanchang 330006, China; 3jiangxi Academy of Medical Sciences, Nanehang 330006, China) |
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| Abstract: | Dendritic cells （DCs） are the most potent antigen-presenting cells （APCs） which have the dual capacities in regulating immune response and immune tolerance depending on their maturation and surface markers. The function of DCs is associated with its maturation degree. Immature DCs mediate immune tolerance while the matured DCs play a critical role in tumor immunity. We will summarize DCs＇ heterogeneity and the relationship between DCs and tumor immunity in this review. |
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| Keywords: | DC heterogeneity tumor immunity |
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