| 炎症体研究进展 |
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| 引用本文： | 吴丹,黄志伟.炎症体研究进展[J].细胞生物学杂志,2013(10):1426-1433. |
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| 作者姓名： | 吴丹 黄志伟 |
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| 作者单位： | 哈尔滨工业大学生命科学与技术学院,哈尔滨150080 |
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| 摘 要： | 炎症体（innammasome）是一种多蛋白复合体，通过激活半胱天冬酶一l（caspase－1）调控白细胞介素－lβ（IL－1β）和IL－18的加工和成熟，进而参与机体的免疫反应。炎症体作为炎症和细胞死亡的重要调节因子，在天然免疫和免疫炎性疾病的发展中具有重要作用。该文就炎症体的结构与作用机制、信号调节及相关疾病等几方面的最新研究进展作一综述。
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| 关 键 词： | 炎症休 炎症 免疫反应 白细胞介索－1β |
Research Advances in Inflammasome |
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| Wu Dan,Huang Zhiwei.Research Advances in Inflammasome[J].Chinese Journal of Cell Biology,2013(10):1426-1433. |
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| Authors: | Wu Dan Huang Zhiwei |
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| Institution: | ＊ (School of Life, Science and Technology, Harbin Institute of Technology, Harbin 150080, China) |
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| Abstract: | lnflammasome, a kind of polyprotein complexes, can activate caspase-1, regulate interleukin- 1β （IL-lbeta） and I L-I 8 processing and mature, thereby inducing the body＇s immune response. As the important regulatory factor of inflammation and cell death, inflammasome plays an important role in innate immunity and inflammatory disease development. In this review, we focus on the recent progress in the studies of the structure of inflammasome, mechanism of inflammation and related diseases and so on. |
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| Keywords: | inflammasome inflammation immune response IL-1β |
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