The effects of phospholipid and factor Va on the inhibition of factor Xa by antithrombin III |
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| Authors: | F J Walker C T Esmon |
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| Affiliation: | Section of Experimental Pathology and Medicine University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma 73190 USA |
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| Abstract: | The rate of inhibition of Factor Xa by antithrombin III was found to be influenced by either phospholipid or Factor Va combined with phospholipid. Our results confirmed that Factor Va and phospholipid could protect Factor Xa from inhibition. However, when antithrombin III levels were extrapolated to infinity, the protective effect of lipid and Factor Va were eliminated and the rate of inhibition was accelerated. This indicated that the protective effect that was observed at low antithrombin III concentrations in the presence of phospholipid and Factor Va was due to inhibition of binding of the inhibitor to Factor Xa. |
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