Heteroarylisopropylamines as MAO inhibitors |
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| Authors: | Vallejos Gabriel Fierro Angélica Rezende Marcos Caroli Sepúlveda-Boza Silvia Reyes-Parada Miguel |
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| Affiliation: | Facultad de Química y Biología, Universidad de Santiago, Casilla 40, Correo 33, Santiago, Chile. |
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| Abstract: | The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin. |
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