Cloning and expression of <Emphasis Type="Italic">R-Spondin1</Emphasis>in different vertebrates suggests a conserved role in ovarian development |
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| Authors: | Craig A Smith Christina M Shoemaker Kelly N Roeszler Joanna Queen David Crews Andrew H Sinclair |
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| Institution: | (1) The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, 3052, Australia;(2) Section of Integrative Biology, University of Texas, Austin, Texas, USA |
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| Abstract: | Background R-Spondin1 (Rspo1) is a novel regulator of the Wnt/β-catenin signalling pathway. Loss-of-function mutations in human RSPO1 cause testicular differentiation in 46, XX females, pointing to a role in ovarian development. Here we report the cloning
and comparative expression analysis of R-SPONDIN1 orthologues in the mouse, chicken and red-eared slider turtle, three species with different sex-determining mechanisms. Evidence
is presented that this gene is an ancient component of the vertebrate ovary-determining pathway. |
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