Developmental expression of the alpha-skeletal actin gene |
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Authors: | Laura D Bertola Elisabeth B Ott Sander Griepsma Freek J Vonk Christoph P Bagowski |
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Institution: | (1) Institute of Biology, Department of Integrative Zoology, University of Leiden, 2333, AL Leiden, The Netherlands |
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Abstract: | Background Actin is a cytoskeletal protein which exerts a broad range of functions in almost all eukaryotic cells. In higher vertebrates,
six primary actin isoforms can be distinguished: alpha-skeletal, alpha-cardiac, alpha-smooth muscle, gamma-smooth muscle,
beta-cytoplasmic and gamma-cytoplasmic isoactin. Expression of these actin isoforms during vertebrate development is highly
regulated in a temporal and tissue-specific manner, but the mechanisms and the specific differences are currently not well
understood. All members of the actin multigene family are highly conserved, suggesting that there is a high selective pressure
on these proteins. |
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Keywords: | |
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