Profiling of serum and tissue high abundance acute-phase proteins of patients with epithelial and germ line ovarian carcinoma |
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| Authors: | Yeng Chen Boon-Kiong Lim Suat-Cheng Peh Puteri Shafinaz Abdul-Rahman Onn Haji Hashim |
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| Affiliation: | (1) Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;(2) Department of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;(3) Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia |
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| Abstract: | Background Acute-phase response involves the simultaneous altered expression of serum proteins in association to inflammation, infection, injury or malignancy. Studies of the acute-phase response usually involve determination of the levels of individual acute-phase serum proteins. In the present study, the acute-phase response of patients with epithelial (EOCa) and germ-line (GOCa) ovarian carcinoma was investigated using the gel-based proteomic approach, a technique which allowed the simultaneous assessment of the levels of the acute-phase serum high abundance proteins. Data obtained were validated using ELISA and immunostaining of biopsy samples. |
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