Ebp1 expression in benign and malignant prostate |
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| Authors: | Philippe O Gannon Ismaël Hervé Koumakpayi Cécile Le Page Pierre I Karakiewicz Anne-Marie Mes-Masson Fred Saad |
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| Institution: | 1.Centre de recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal,Montreal,Canada;2.Cancer Prognostics and Health Outcomes Unit & Department of Surgery,H?pital St-Luc (CHUM),Montreal,Canada;3.Department of Medicine,Université de Montréal,Montreal,Canada;4.Department of Surgery, CHUM,Université de Montréal,Montreal,Canada |
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| Abstract: | Background ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other
members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate
in prostate cancer progression in vivo. Therefore, the present study examines Ebp1 expression in cancerous and non-cancerous prostates tissues. Ebp1 expression
was also correlated to known Ebp1 regulated proteins (Androgen receptor (AR), Cyclin D1 & ErbB3) and the proliferation marker
Ki67. Furthermore we evaluated whether Ebp1 expression correlated with biochemical recurrence (BCR) following radical prostatectomy. |
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