Identification and typing of human enterovirus: a genomic barcode approach |
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| Authors: | Wei Chengguo Wang Guoqing Chen Xin Huang Honglan Liu Bin Xu Ying Li Fan |
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| Institution: | Department of Pathogeny Biology, Norman Bethune Medical College of Jilin University, Changchun, Jilin, China. |
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| Abstract: | Identification and typing of human enterovirus (HEVs) are important to pathogen detection and therapy. Previous phylogeny-based typing methods are mainly based on multiple sequence alignments of specific genes in the HEVs, but the results are not stable with respect to different choices of genes. Here we report a novel method for identification and typing of HEVs based on information derived from their whole genomes. Specifically, we calculate the k-mer based barcode image for each genome, HEV or other human viruses, for a fixed k, 1
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