Long-lasting Changes of Albino Rats Behavior and Brain Bioamines Content After Immunization Against Cholecystokinin-3 and -4 |
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| Authors: | Igor Petrovich Ashmarin Raisa A. Danilova Maria F. Obukhova Olga Igorevna Rud’ko Ludmila A. Andreeva |
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| Affiliation: | (1) Department of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow, Russia;(2) Institute of Molecular Genetics, Moscow, 119922, Russia |
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| Abstract: | Active immunization against cholecystokinin fragments 31–33 (CCK-3) and 30–33 (CCK-4) results in long-lasting changes of albino rats’ behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior. |
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| Keywords: | Peptides CCK-3 CCK-4 Active immunization Behavior Bioamines Rats |
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