抗黄体酮联合Aromatase抑制剂或iNOS终止恒河猴妊娠

[目的]评价抗黄体酮(mifepristone)联合Aromatase抑制剂(letrozole或aminoglutethimide)或iNOS抑制剂(aminoguandine)是否能有效终止恒河猴早期妊娠。[方法]将30只猴子随机分为5组(治疗组每组6只,对照组6只),并在妊娠30,31和32天进行如下处理:对照组,每只动物1ml安慰剂;A组,Mifepristone(1mg/kg,sc.);B组,Mifepristone(sc.)+Letrozole(2.5mg/只sc.);C组,Mifepristone(1mg/kg,sc.)+aminoglute-chimide(50mg/kgsc.,bid);D组,Mifepristone(1mg/kg,sc.)+aminoguanidine(150mg/kg,sc.,bid)。所有妊娠猴在妊娠29天通过超声波确认。[结果]在B、C、D组,所有的动物的妊娠都在妊娠早期被终止(6/6)。A组和对照组的妊娠终止率分别为3/6和2/6。同时,联合用药能够有效排空子宫腔和减少出血。[结论]该处理能有效地终止恒河猴早期妊娠。联合用药比用于女人的妊娠治疗更有效,并减少了流血时间,或许可以代替目前的终止妊娠的医疗方法。

Medical Termination of Pregnancy in Macaca Mulatta Using Combinations of an Antiprogestin +Aromatase or Nitric Oxide Inhibitors

[Objective] To evaluate whether the combination of an antiprogestin (mifepristone) +aromatase inhibitors (letrozole or aminoglutethimide) or an iNOS inhibitor (aminoguandine) are effective in ending pregnancy during early gestation in rhesus monkeys. [Methods] The 30 pregnant monkeys were be randomly assigned five groups (treatment group:6 animals per group, but for 6 animals in control group) and to be undergone treatment with control group : Placebo (1ml/animal,), group A: Mifepristone (1mg/kg, sc.,), group B: Mifepristone(sc.) + Letrozole(2.5mg/animals, sc. ), group C: Mifepristone(1mg/kg,sc.) + aminoglutethimide(50mg/kg sc., bid,) and group D: Mifepristone(1mg/kg,sc.) + aminoguanidine(150mg/kg, sc., bid,) on d30, 31, and 32 of gestation. all the pregnant monkeys were be identified by ultrasound instrument on d29 of gestation. [Results] These results shown that 6/6 the animals in group B, C and D were effectively terminate the early pregnancy, the 3/6 animals in group A were be terminated pregnancy, and the 2/8 animals in control group were be terminated after treatment, and these combinations could also result in effective evacuation of the uterine cavity and reduce bleeding. [Conclusion] The paper suggested that the treatment will effectively terminate the early pregnancy in rhesus monkeys, the combination of agents used was likely to be more effective than the therapy in women and could reduce the long duration of bleeding associated with the present treatment, and might replace present therapy for medical abortion.