FERRITIN PARTICLES IN MACROPHAGES AND IN ASSOCIATED MAST CELLS |
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Authors: | J. V. Simson and S. S. Spicer |
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Affiliation: | From the Institute of Pathobiology, Pathology Department, Medical University of South Carolina, Charleston, South Carolina 29401 |
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Abstract: | In a variety of tissues (lymph node and glandular stroma), mast cells have been found in close and often intimate association with macrophages containing numerous ferritin-like particles in their cytoplasm and within cytoplasmic vacuoles (siderosomes). Phagocytic vacuoles in a given macrophage differed markedly. Some contained abundant Prussian blue-reactive material and others contained periodic acid-Schiff reactive substance at the light microscope level, and ultrastructurally some were filled with ferritin particles and others were not. Ferritin-like particles have also been observed occasionally in the mast cells associated with macrophages and even within the matrix of some of the granules in these mast cells. |
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