Cytoplasmic and nuclear inheritance of resistance to alkylguanidines and ethidium bromide in a petite-negative yeast |
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| Authors: | A Brunner J Mas E Celis J R Mattoon |
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| Institution: | 1. Departmento de Bioquímica, Facultad de Medicina Universidad Nacional Autónoma de México México 20, D.F., México;2. Department of Physiological Chemistry The Johns Hopkins University School of Medicine Baltimore, Maryland 21205 USA |
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| Abstract: | Mutants of the petite-negative yeast, , resistant to the inhibitors of oxidative phosphorylation, decamethylenediguanidine and octylguanidine were isolated from medium containing ethidium bromide. All mutants were resistant to ethidium bromide; some mutants were resistant to both alkylguanidines, some to one, others to neither. Both nuclear and cytoplasmic inheritance of resistance to decamethylenediguanidine and ethidium bromide was demonstrated by tetrad analysis. |
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