Chemical synthesis of dolichyl phosphates, their analogues and derivatives and application of these compounds in biochemical assays |
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Authors: | Danilov Leonid L Druzhinina Tatyana N |
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Institution: | N.K. Kochetkov Laboratory of Carbohydrate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia. |
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Abstract: | Several methods for simple and efficient chemical synthesis of dolichyl phosphates and their analogues and derivatives are briefly summarized with a special emphasis on chemical modification of phosphoryl group and preparation of dolichyl phosphates labelled at the omega-end and at the gamma-isoprene unit of the isoprene chain by fluorescent groups, 2-aminopyridine and 1-aminonaphtalene residues. Additionally, data on biochemical assays with application of the compounds mentioned above are presented. |
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