Contribution of mechanical factors to arrhythmogenesis in calcium overloaded cardiomyocytes: model predictions and experiments |
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Authors: | Katsnelson Leonid B Solovyova Olga Balakin Alexander Lookin Oleg Konovalov Pavel Protsenko Yuri Sulman Tatiana Markhasin Vladimir S |
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Affiliation: | a Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya str, Ekaterinburg 620049, Russian Federation b Ural Federal University, 19 Mira str, Ekaterinburg 620002, Russian Federation |
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Abstract: | It is well-known that Ca2+ overload in cardiomyocytes may underlie arrhythmias. However, the possible contribution of mechanical factors to rhythm disturbances in Ca2+ overloaded myocytes has not been sufficiently investigated. We used a mathematical model of the electrical and mechanical activity of cardiomyocytes to reveal an essential role of the mechanisms of cardiac mechano-electric feedback in arrhythmogenesis in Ca2+ overloaded myocardium. In the model, the following mechanical factors increased Ca2+ overload in contracting cardiomyocytes and promoted rhythm disturbances: i) a decrease in the mechanical load for afterloaded contractions; and ii) a decrease in the initial length of sarcomeres for isometric twitches. In exact accordance with the model predictions, in experiments on papillary muscles from the right ventricle of guinea pigs with Ca2+ overloaded cardiomyocytes (using 0.5-1 μM of ouabain), we found that emergence of rhythm disturbances and extrasystoles depends on the mechanical conditions of muscle contraction. |
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Keywords: | Myocardium mechanics Heart rhythm Extrasystole Mechano-electric coupling |
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