Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells |
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Authors: | D A Carson E H Willis N Kamatani |
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Affiliation: | Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road La Jolla, California 92037 USA |
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Abstract: | Viable human and murine lymphoblasts, and normal human tissue extracts, converted the thioether nucleosides 5'-methylthioadenosine (MeSAdo) and 5'-methylthioinosine (MeSIno) to methionine. Both MeSAdo and MeSIno, but not homocysteine, supported the short-term growth of human or murine lymphoblasts in methionine deficient medium. However, MeSAdo at concentrations greater than 25 microM inhibited cell growth. MeSIno was non-toxic at concentrations up to 200 microM, and supported the long-term growth of lymphoblasts in methionine-free medium. |
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Keywords: | MeSAdo 5′-deoxy-5′-methylthioadenosine MeSIno 5′-deoxy-5′-methylthioinosine |
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