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Non-linear viscoelastic behavior of abdominal aortic aneurysm thrombus
Authors:Evelyne A van Dam  Susanne D Dams  Gerrit W M Peters  Marcel C M Rutten  Geert Willem H Schurink  Jaap Buth  Frans N van de Vosse
Institution:(1) Department of Biomedical Engineering, Technische Universiteit Eindhoven, PO box 513, WH4.120, 5600 MB Eindhoven, The Netherlands;(2) Department of Mechanical Engineering, Technische Universiteit Eindhoven, Eindhoven, Netherlands;(3) Department of Vascular Surgery, University Hospital Maastricht, Maastricht, Netherlands;(4) Department of Vascular Surgery, Catharina Hospital Eindhoven, Eindhoven, Netherlands
Abstract:The objective of this work was to determine the linear and non-linear viscoelastic behavior of abdominal aortic aneurysm thrombus and to study the changes in mechanical properties throughout the thickness of the thrombus. Samples are gathered from thrombi of seven patients. Linear viscoelastic data from oscillatory shear experiments show that the change of properties throughout the thrombus is different for each thrombus. Furthermore the variations found within one thrombus are of the same order of magnitude as the variation between patients. To study the non-linear regime, stress relaxation experiments are performed. To describe the phenomena observed experimentally, a non-linear multimode model is presented. The parameters for this model are obtained by fitting this model successfully to the experiments. The model cannot only describe the average stress response for all thrombus samples but also the highest and lowest stress responses. To determine the influence on the wall stress of the behavior observed the model proposed needs to implemented in the finite element wall stress analysis.
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