Time Modulation Effect of Diethyldithiocarbamate (DDC) on Radiosensitization by Superoxide Dismutase (SOD) Inhibition |
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| Authors: | Charles Kent Gerry Blekkenhorst |
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| Affiliation: | a Research Institute for Medical Biophysics, Medical Research Council, Tygerberg, South Africab Dept. of Radiotherapy, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa |
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| Abstract: | Superoxide dismutase (SOD) is known to protect cells from the lethal effects of ionizing radiation by the dismutation of oxygen radicals. Diethyldithiocarbamate (DDC) is known inhibitor of SOD and may therefore be useful as a radiosensitizer. DDC however, is also a thinly radio protector due to its ability to scavenge radiation induced free radicals. We have shown that DDC. if administered to turnours 1 hour prior to x-irradiation exerts a protective effect, whereas if administered 4 hours prior to irradiation, it radiosensitizes. This time modulation effect is not apparent after neutron irradiation where DDC protects in both situations. We have also examined the effect of DPC on the LD50/30 in mice after total body irradiation. |
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| Keywords: | Radiosensitization radioprotection superoxide dismutase diethyldithiocarbamate |
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