Dexamethasone Down-Regulates the Expression of microRNA-155 in the Livers of Septic Mice |
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| Authors: | Zhong-hua Wang Yan-bing Liang Hao Tang Zhi-bin Chen Zhen-yu Li Xu-chu Hu Zhong-fu Ma |
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| Institution: | 1. Department of Intensive Care Unit, Guangdong General Hospital, Guangzhou, Guangdong, China.; 2. Department of General Internal Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.; 3. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.; University of North Dakota, United States of America, |
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| Abstract: | To investigate the expression of microRNA-155 (miRNA-155) in the livers of mice with lipopolysaccharide (LPS)-induced sepsis and to determine the role of dexamethasone (DXM) in the regulation of miRNA-155 expression, we pretreated mice with or without DXM prior to LPS exposure. Our study demonstrated that the expression of miRNA-155 and inflammatory factors increased in the liver tissues of mice with LPS-induced sepsis and that DXM down-regulated their expression in a dose-dependent manner. Moreover, DXM alone inhibited the expression of miRNA-155 to below the baseline level, but did not impact the expression of inflammatory factors, suggesting that the down-regulation of miRNA-155 by DXM may partially, but not completely, depend on the suppression of pro-inflammatory cytokines by DXM. Our data indicate that the overexpression of miRNA-155 in the livers of mice with LPS-induced sepsis may play an important role in the pathological processes of sepsis and that the down-regulation of miRNA-155 by DXM may be a novel mechanism regulating inflammation and immunity. |
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