| 24p3-24p3受体系统：一种新的铁转运途径 |
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| 引用本文： | 赵颂民,石振华,段相林,常彦忠.24p3-24p3受体系统：一种新的铁转运途径[J].生物化学与生物物理进展,2007,34(6):557-561. |
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| 作者姓名： | 赵颂民 石振华 段相林 常彦忠 |
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| 作者单位： | 河北师范大学,河北省动物生理生化与分子生物学重点实验室,石家庄,050016 |
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| 基金项目： | 国家自然科学基金;河北省自然科学基金 |
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| 摘 要： | 小鼠24p3是脂质运载蛋白lipocalin家族的成员之一,可在白介素3(interleukin-3,IL-3)缺乏时诱导细胞发生凋亡,并参与细胞的铁转运过程.最近,Devireddy等又成功克隆到了24p3的细胞表面受体(24p3 receptor,24p3R),进一步确定了24p3-24p3R这一新的铁转运途径.该途径的发现不仅增加了对铁转运理论新的认识,更重要的是,这一发现为铁代谢调控细胞凋亡理论的建立奠定了基础.
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| 关 键 词： | 24p3-24p3 受体系统 铁转运 细胞凋亡 |
| 收稿时间： | 2006/11/23 0:00:00 |
| 修稿时间： | 2006-11-23 |
24p3-24p3 Receptor System: A New Pathway of Iron Transport |
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| ZHAO Song-Min,SHI Zhen-Hu,DUAN Xiang-Lin and CHANG Yan-Zhong.24p3-24p3 Receptor System: A New Pathway of Iron Transport[J].Progress In Biochemistry and Biophysics,2007,34(6):557-561. |
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| Authors: | ZHAO Song-Min SHI Zhen-Hu DUAN Xiang-Lin and CHANG Yan-Zhong |
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| Institution: | The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050016, China;The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050016, China;The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050016, China;The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050016, China |
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| Abstract: | The 24p3 of mouse is a member of lipocalin family and it has been implicated in iron transport and apoptosis due to interleukin-3(IL-3) deprivation. Devireddy and colleagues cloned the receptor of 24p3 and further confirmed that the pathway of 24p3-24p3R is a new iron transport approach in Dec 2005. A link between iron internalization mediated by 24p3R and regulation of apoptosis was suggested. |
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| Keywords: | 24p3-24p3R pathway iron transport cell apoptosis |
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