The autoimmune mouse MRL/Mp-lpr/lpr contains cells with spontaneous cytotoxic activity against target cells bearing self-determinants |
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Authors: | S Muraoka R G Miller |
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Institution: | Ontario Cancer Institute, Toronto, Canada. |
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Abstract: | Spontaneously cytotoxic cells possessing specificity and having a complex pattern of reactivity directed at least partly against self-determinants develop by the age of 10 weeks in the autoimmune mouse strain MRL/Mp-lpr/lpr (MRL-lpr) and by the age of 6 months in C57BL/6-lprl/lpr. Similar effector cells do not develop in either MRL/Mp-+/+(MRL-+/+) or normal C57BL/6 mice up to 6 months old. Freshly prepared suspensions of both lymph node and bone marrow cells from individual MRL-lpr mice could kill Con A- or LPS-induced blast cells and fresh thymocytes from MRL-+/+ and other mouse strains with strong preference for strains carrying (self)-H-2k determinants in a 4-hr51Cr release assay. These results imply that self-reactive cells are generated as part of the lpr gene defect. |
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