Association of CHRNA4 polymorphism with depression and loneliness in elderly males |
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Authors: | Tsai S-J Yeh H-L Hong C-J Liou Y-J Yang A C Liu M-E Hwang J-P |
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Affiliation: | Department of Psychiatry, Taipei Veterans General Hospital School of Medicine, National Yang-Ming University, Taipei, Taiwan. |
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Abstract: | The cholinergic receptor, nicotinic, alpha 4 (CHRNA4) gene encodes the neuronal nicotinic acetylcholine receptor alpha-4 subunit. Recent research has shown that a variation in CHRNA4 (rs1044396) affects attention and negative emotionality in normal adults. To determine the link between CHRNA4 variation and cognitive function/depressed mood, this study conducted a genotype-phenotype correlation analysis between the common CHRNA4:rs1044396 variant and several baseline parameters of cognition and depressed mood in 192 elderly male subjects without major psychiatric disorders or dementia. Study findings identified a significant link between the CHRNA4:rs1044396 polymorphism and depression and loneliness in the aged. Compared to carriers of at least one T-allele, carriers of the homozygous C/C genotype described themselves as more depressed and lonely. This is the first evidence which may implicate CHRNA4 in depressed emotions in the elderly. |
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Keywords: | Aged attention CHRNA4 depression polymorphism |
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