Intrinsic protein disorder in human pathways |
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Authors: | Fong Jessica H Shoemaker Benjamin A Panchenko Anna R |
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Institution: | National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. fongj@ncbi.nlm.nih.gov |
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Abstract: | We analyze human-specific KEGG pathways trying to understand the functional role of intrinsic disorder in proteins. Pathways provide a comprehensive picture of biological processes and allow better understanding of a protein's function within the specific context of its surroundings. Our study pinpoints a few specific pathways significantly enriched in disorder-containing proteins and identifies the role of these proteins within the framework of pathway relationships. Three major categories of relations are shown to be significantly enriched in disordered proteins: gene expression, protein binding and to a lesser degree, protein phosphorylation. Finally we find that relations involving protein activation and to some extent inhibition are characterized by low disorder content. |
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