The presynaptic active zone protein RIM1alpha is critical for normal learning and memory |
| |
Authors: | Powell Craig M Schoch Susanne Monteggia Lisa Barrot Michel Matos Maria F Feldmann Nicole Südhof Thomas C Nestler Eric J |
| |
Institution: | Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. craig.powell@utsouthwestern.edu |
| |
Abstract: | The active zone protein RIM1alpha is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1alpha(-/-) mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality. Our data suggest that a decrease in release probability or a loss of presynaptic LTP alone is not sufficient to cause major behavioral alterations, but the combination of presynaptic abnormalities in RIM1alpha(-/-) mice severely alters learning and memory. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|