Synthesis of carbazole bearing pyridopyrimidine‐substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity |
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| Authors: | Arleta Rifati‐Nixha Mustafa Arslan Nahit Gener Kübra &#x;kr&#x;k&#x;&#x; Baak Gke Oktay Arslan |
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| Institution: | Arleta Rifati‐Nixha,Mustafa Arslan,Nahit Gençer,Kübra Ç?kr?k?ç?,Ba?ak Gökçe,Oktay Arslan |
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| Abstract: | The synthesis of carbazole containing pyridopyrimidine‐substituted sulfonamide derivatives ( 3a‐i ) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active ( K i: 14 µM) for hCA I and 3f ( K i: 126 µM) for hCA II. |
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| Keywords: | carbazole carbonic anhydrase pyridopyrimidine sulfonamide |
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