Resveratrol Protects against Cigarette Smoke–Induced Oxidative Damage and Pulmonary Inflammation

This study was carried out to investigate the effects of resveratrol on cigarette smoke (CS)–induced lung injury. Experimental mice were administrated with 1 mg/kg or 3 mg/ kg resveratrol orally, 1 h prior to CS exposure (five cigarettes a day for 3 consecutive days). Airway inflammation and gene expression changes were assessed. CS exposure increased the number of pulmonary inflammatory cells, coupled with elevated production of tumor necrosis factor α and interleukin‐6 in bronchoalveolar lavage fluids. Resveratrol treatment decreased CS‐induced lung inflammation. Resveratrol restored the activities of superoxide dismutase, GSH peroxidase, and catalase in CS‐treated mice. CS significantly enhanced the nuclear translocation of nuclear factor κB (NF‐κB) and NF‐κB DNA binding activity, which was impaired by resveratrol pretreatment. In addition, resveratrol promoted CS‐induced heme oxygenase‐1 (HO‐1) expression and activation. Our results collectively indicate that resveratrol attenuates CS‐induced lung oxidative injury, which involves decreased NF‐κB activity and the elevated HO‐1 expression and activity.