糖基化对Notch信号传递系统的影响

Notch信号分子是多细胞生物发育过程中高度保守的一类十分重要的跨膜信 号受体糖蛋白家族.这一信号途径通过局部细胞间的相互作用而产生对多种不成熟细胞分化 的抑制信号, 精确调控细胞的分化潜能，在细胞发育、增殖、分化中起关键作用,参与造血 、T细胞发育、血管生成等重要生理过程.Notch受体分子上具有多种寡糖链，包括N-聚糖、O-岩藻糖聚糖、O-葡萄糖聚糖等，这些寡糖以及相关糖基转移酶对Notch受体-配体结合以及Notch信号传递功能有重要影响.本文就近年来有关Notch受体糖基化及其对Notch信号传递过程的研究进行综述.

Glycosylation Regulates Notch Signaling Pathway

Notch is a heterodimeric, conversed type I transmembrane receptor family that is required for the decision of cell fate throughout the metazoa. Through direct cell-cell interactions, notch plays important roles in critical physiological processes involving cell proliferation and differentiation such as hematogenesis, lymphogenesis and vasculogenesis. Notch receptors are glycosylated on their extracellular domains. The glycans, including N-glycan, O-fucose glycan and O-glucose glycan, and their synthetic glycosyltransferase were reported to be important in Notch receptor-ligand interaction and the regulation of Notch signaling transduction. The recent research progress on Notch glycosylation were summarized in this review.