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EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer
Authors:Xi Chen  Mamoru Takada  Cheng Fan  Xingnan Zheng  Haitao Wen  Yong Liu  Chenguang Wang  Richard G Pestell  Katherine M Aird  William G Kaelin Jr  Xiaole Shirley Liu  Qing Zhang
Institution:1. Department of Molecular and Cellular Biology, The Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA;2. Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA;3. Department of Surgery, University of North Carolina, Chapel Hill, NC, USA;4. Program of Radiation Protection and Drug Discovery, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China;5. Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA;6. Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA;7. Department of Medical Oncology, Dana‐Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;8. Howard Hughes Medical Institute, Chevy Chase, MD, USA;9. Department of Biostatistics and Computational Biology, Dana‐Farber Cancer Institute and Harvard School of Public Health, Boston, MA, USA;10. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
Abstract:
Keywords:EglN2  hypoxia  mitochondria  NRF1  tumorigenesis
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