首页 | 本学科首页   官方微博 | 高级检索  
     


Blocking integrin inactivation as an anti‐angiogenic therapy
Authors:Pipsa Saharinen  Johanna Ivaska
Affiliation:1. Wihuri Research Institute and Research Programs Unit, Translational Cancer Biology Program and Department of Virology, University of Helsinki, Helsinki, Finland;2. Department of Food and Biochemistry, Turku Centre for Biotechnology, University of Turku, Turku, Finland
Abstract:During angiogenesis, endothelial cell migration is coordinated by integrin‐mediated contact with the extra‐cellular matrix (ECM), coupled with receptor tyrosine kinase signalling to regulate dynamic cytoskeletal and plasma membrane reorganization. A recent paper by Vitorino et al ( 2015 ) defined a new MAP4K4–moesin–talin–β1‐integrin pathway that could be therapeutically exploited to suppress pathologic angiogenesis.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号