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Suppression of miR‐199a maturation by HuR is crucial for hypoxia‐induced glycolytic switch in hepatocellular carcinoma
Authors:Ling‐Fei Zhang  Jia‐Tao Lou  Ming‐Hua Lu  Chunfang Gao  Shuang Zhao  Biao Li  Sheng Liang  Yong Li  Dangsheng Li  Mo‐Fang Liu
Affiliation:1. Center for RNA Research, State Key Laboratory of Molecular Biology‐University of Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;2. Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;3. Department of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China;4. Department of Laboratory Medicine, Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, China;5. Department of Nuclear Medicine and Micro PET Center, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;6. Department of Nuclear Medicine, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;7. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;8. Shanghai Information Center for Life Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Abstract:
Keywords:glycolysis  hepatocellular carcinoma  HK2 and PKM2  hypoxia  miR‐199a
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