JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection |
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| Authors: | Hairu Yang Jesper Kronhamn Jens‐Ola Ekström Gül Gizem Korkut Dan Hultmark |
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| Institution: | 1.Department of Molecular Biology, Umeå University, Umeå, Sweden;2.Institute of Biomedical Technology, BMT, Tampere University, Tampere, Finland;3.Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Uppsala, Sweden |
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| Abstract: | The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection. |
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| Keywords: |
Drosophila
innate immunity JAK/STAT signaling muscles |
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