Expression of integrins during axolotl limb regeneration |
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Authors: | Panagiotis A. Tsonis Kathleen Doane Katia Del Rio-Tsonis |
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Affiliation: | Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469-2320.;Department of Anatomy, North Eastern Ohio University College of Medicine, 4209 State Rt 44, Rootstown, OH 44272-0095, USA. |
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Abstract: | Limb regeneration in urodeles is achieved through the dedifferentiation of tissues at the amputation plane and through the production of the blastema. This tissue breakdown is possible by extensive alterations in molecules of the extracellular matrix. In this respect we describe the regulation of several integrins during such events. It was found that α1 and β1 integrins were down-regulated as blastema formation proceeded. In contrast, the expression of α3, α6 and αv integrins were upregulated in the blastema. These data are consistent with the roles of integrins in developmental phenomena and are discussed in light of the mechanisms of dedifferentiation. |
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Keywords: | cell adhesion dedifferentiation lens regeneration limb regeneration urodeles |
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