Analysis of ibuprofen in serum by capillary electrophoresis |
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| Affiliation: | 1. Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland;2. Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland;1. Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, Perugia 06123, Italy;2. Perm National Research Polytechnic University, 29 Komsomolsky Al., Perm 614990, Russia;3. Perm State Medical University, 26 Petropavlovskaya St., Perm 614990, Russia |
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| Abstract: | A rapid method for analysis of the analgesic drug ibuprofen in serum by capillary zone electrophoresis in a borate buffer 160 mmol/l pH 8.5 is described. The method involves deproteinization with acetonitrile to remove serum proteins followed by direct injection on the capillary. The recoveries of standards added to the serum were 84–92%. The method is suited for analysis of samples with concentrations >10 mg/l. Many other analgesics such as ketoprofen, daypro and salicylates can also be determined by this method. |
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