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Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents |
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| Authors: | Jeong Lak Shin Lee Jeong A Kim Hea Ok Tosh Dilip K Moon Hyung Ryong Lee Seung-Jin Lee Kang Man Sheen Yhun Y Chun Moon Woo |
| Affiliation: | College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr |
| Abstract: | Novel 2'-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps. |
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