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细菌中常见的蛋白翻译后修饰
引用本文:郑学学,朱力,廖祥儒,王恒樑. 细菌中常见的蛋白翻译后修饰[J]. 生物技术通讯, 2009, 20(4): 568-571. DOI: 10.3969/j.issn.1009-0002.2009.04.034
作者姓名:郑学学  朱力  廖祥儒  王恒樑
作者单位:1. 江南大学,生物工程学院,江苏,无锡,214062;军事医学科学院,生物工程研究所,北京,100071
2. 军事医学科学院,生物工程研究所,北京,100071
3. 江南大学,生物工程学院,江苏,无锡,214062
摘    要:蛋白质的翻译后修饰在生物体生命活动中发挥着重要作用,大部分蛋白质都会经历翻译后修饰。对这些修饰的了解和掌握非常重要,因为这些修饰可能会改变蛋白质的物理及化学性质,如折叠、构象、稳定性及活性,从而改变蛋白的功能。此外,修饰基团本身也可能具有某些功能。因此,分析研究蛋白质翻译后修饰具有重要意义。细菌中常见的翻译后修饰过程有糖基化、磷酸化和乙酰化,我们简要综述了这几种修饰过程。

关 键 词:细菌  翻译后修饰  磷酸化  糖基化  乙酰化

Post-Translational Modification for Bacteria Protein
ZHENG Xue-Xue,ZHU Li,LIAO Xiang-Ru,WANG Heng-Liang. Post-Translational Modification for Bacteria Protein[J]. Letters in Biotechnology, 2009, 20(4): 568-571. DOI: 10.3969/j.issn.1009-0002.2009.04.034
Authors:ZHENG Xue-Xue  ZHU Li  LIAO Xiang-Ru  WANG Heng-Liang
Affiliation:Liang(1. School of Biotechnology, Jiangnan University, Wuxi 214062; 2. Beijing Institute of Biotechnology, Beijing 100071; China)
Abstract:Protein post-translational modifications play an important role in life activities of organisms, and most proteins undergo post-translational modifications. Knowledge of these modifications is extremely important because modifications may alter physical and chemical properties, such as folding, conformation distribution, stability, activity, and consequently, function of the proteins. Moreover, the modification itself can act as an added functional group. As a result, the analysis of proteins and their post-translational modifications is significative. In bacteria, glycosylation, phosphorylation and acetylation are the most common modifications. The processes and roles of these post-translational modifications were summarized in this review.
Keywords:bacteria  post-translational modification  glycosylation  pbosphorylation  acetylation
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