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Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids
Authors:Benedetta Artegiani  Lisa van Voorthuijsen  Rik GH Lindeboom  Daniëlle Seinstra  Inha Heo  Pablo Tapia  Carmen López-Iglesias  Daniel Postrach  Talya Dayton  Rurika Oka  Huili Hu  Ruben van Boxtel  Johan H van Es  Johan Offerhaus  Peter J Peters  Jacco van Rheenen  Michiel Vermeulen  Hans Clevers
Institution:1. Oncode Institute, Utrecht, the Netherlands;2. Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands;3. Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University Nijmegen, Nijmegen, the Netherlands;4. Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands;5. The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, 6229ER Maastricht, the Netherlands;6. The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands;7. The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Genetics, School of Basic Medical Sciences, Shandong University, 250012 Jinan, China;8. Department of Pathology, UMC Utrecht, 3584CX Utrecht, the Netherlands;9. University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands
Abstract:
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  • Keywords:Corresponding author  human organoids  liver  cancer  cholangiocarcinoma  CRISPR/Cas9  BAP1  tumor modeling  genome editing  epigenetics
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