The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease |
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| Authors: | Jie Liu Charlene Supnet Suya Sun Hua Zhang Levi Good Elena Popugaeva Ilya Bezprozvanny |
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| Affiliation: | 1.Department of Physiology; University of Texas Southwestern Medical Center Dallas; Dallas, TX USA;2.Department of Neurology and Neurotherapeutics; University of Texas Southwestern Medical Center Dallas; Dallas, TX USA;3.Laboratory of Molecular Neurodegeneration (LMN); St. Petersburg State Polytechnical University; St. Petersburg, Russia |
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| Abstract: | Dysregulated endoplasmic reticulum (ER) calcium (Ca2+) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca2+ release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models. The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology. |
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| Keywords: | ryanodine receptor Arc spontaneous activity amyloid load spine morphology EEG caffeine |
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